12/17/2023 0 Comments Nasdaq alt![]() ![]() The trial met its primary endpoint in all pemvidutide treatment groups. Twenty-seven (29%) subjects had type 2 diabetes at baseline, and approximately 75% of study subjects were of Hispanic ethnicity. Mean BMI at baseline was approximately 36 kg/m 2 and mean liver fat content (LFC), as measured by MRI-PDFF, was approximately 22%. Ninety-four (94) subjects were randomized and treated at 13 sites across the U.S. The trial was conducted without adjunctive diet and exercise interventions that are the standard for obesity trials. The primary efficacy endpoint was the percent (%) reduction in liver fat content from baseline, and the key secondary efficacy endpoint was the % weight loss from baseline, both at 12 weeks of treatment. No dose titration was used with 1.2 mg or 1.8 mg dose, while a short 4-week dose titration was employed at the 2.4 mg dose. Subjects were randomized 1:1:1:1 to 1.2 mg, 1.8 mg, 2.4 mg pemvidutide or placebo administered weekly for 12 weeks. Harrison, Medical Director, Pinnacle Research, serving as the Principal Investigator. The trial was a randomized, double-blind, placebo-controlled study, with Dr. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, today announced positive topline results from its 12-week Phase 1b study of pemvidutide 1 in subjects with non-alcoholic fatty liver disease (NAFLD). 14, 2022 (GLOBE NEWSWIRE) - Altimmune, Inc. Altimmune to host conference call today at 8:30 am ET.Mean weight loss of 4.9% (placebo-adjusted 4.7%) in subjects without diabetes receiving 1.8 mg dose at 12 weeks of treatment. ![]() All 3 pemvidutide dosing groups (1.2 mg, 1.8 mg, 2.4 mg) achieved the primary endpoint of relative and absolute reductions in liver fat, with a 68.5% relative reduction in liver fat content in subjects receiving 1.8 mg dose at 12 weeks of treatment.NASDAQ does not use this value to determine compliance with the listing requirements. "Market Cap" is derived from the last sale price for the displayed class of listed securities and the total number of shares outstanding for both listed and unlisted securities (as applicable). It does not include securities convertible into the common equity securities. ![]() Market Cap (Capitalization) is a measure of the estimated value of the common equity securities of the company or their equivalent. Register for your free account today at. Data Link's cloud-based technology platform allows you to search, discover and access data and analytics for seamless integration via cloud APIs.
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